Endocrine Abstracts

Different diets have been used clinically and/or have been rigorously assessed in the context of clinical trials in the past several years. Relative efficacy in terms of weight loss and improvement of cardiovascular outcomes will be presented. In addition, recent data have emerged on the role of leptin in mediating the neuroendocrine response to long-term caloric derivation and will also be presented along with novel data on leptin resistance. Leptin, alone or in combination w...

My research focuses on the interplay of brain and adipose tissue and the elucidation of the physiology, diagnostic, and therapeutic utility of adipokines and myokines. We defined the central role these compounds play in normal physiology and pathophysiology of several diseases in humans, with the notion that such investigations will eventually lead to new treatments for metabolic and cardiovascular disease. We have also studied in-depth the role of leptin in the brain, definin...

Introduction: Thyroid hormones and irisin increase energy expenditure and induce browning of adipose tissue. However, little is known about irisin physiology and regulation. Here we aim to elucidate whether thyroid hormones alter circulating irisin concentrations in humans.Design and subjects: One cross-sectional (case-control) evaluation and two interventions were performed independently from each other, including previously thyroidectomized patients. C...